2015 Conference

Our annual Lush Prize Conference took place on Friday 20 November, on the theme of:

‘Adverse Outcome Pathways – What, How and Where Next?’ .

Lush-Prize-conference-2105Adverse Outcome Pathways map entire sequences of events from exposure to a chemical through to effects at molecular, cellular, tissue and organ level in the body and beyond, to individuals and populations. 

They offer the potential to greatly improve prediction of health effects and end the use of animals in safety testing. The first pathway for skin sensitisation has now been mapped and tests involved are undergoing regulatory approval. 

But is there realistically an end in sight for animal testing using 21st Century technologies? How many pathways will we need to map? And how long might this take?

We had a day of discussion on this subject with presentations from winners of the 2015 Lush Prize and a range of leading speakers from around the world.

Session 1 – The Skin Sensitisation Adverse Outcome Pathway (AOP)

Chaired by Dr. Gill Langley, Humane Society International (HSI) UK and Lush Prize Judge

David Basketter, DABMEB Consultancy, EUROTOX Registered Toxicologist and Black Box Prizewinner.
Adverse Outcome Pathways: Lessons From Sensitisation
Download this presentation (Powerpoint 6.7MB)

Bob Diderich, Head of Division, Environment Directorate, Organisation for Economic Cooperation and Development (OECD) and Black Box Prizewinner.
OECD’s work on Adverse Outcome Pathways
Download this presentation (Powerpoint 3.6MB)

Terry Schultz, Professor Emeritus, College of Veterinary Medicine, University of Tennessee and Black Box Prizewinner
The Adverse Outcome Pathway(AOP) for Skin Sensitisation (SS): How we got here and where are we going

Download this presentation (Powerpoint 1MB)

Roger Emter, Givaudan in vitro Toxicology Lab, Switzerland and Black Box Prizewinner (with Dr. Andreas Natsch)
The KeratinoSensTM Assay- A test for the AOP of skin sensitization adopted by the OECD
Download this presentation (Powerpoint 3.5MB)



Session 2 – Prize winner Breakout Sessions


A – Young Researcher Prize Winners

Chaired by Rebecca Ram, Lush Prize

Elena Kummer – University of Milan, Italy
Understanding chemical allergen potency through the molecular events that trigger immune cell activation
Download this presentation (Powerpoint 6.5MB)

Bianca Marigliani – Federal University of Sao Paulo, Brazil
Cruelty-free hazard assessment: replacing foetal bovine serum in alternative methods

Download this presentation (Powerpoint 2.9MB)

Jeremy Caplin – Iowa State University, USA
“Placenta-on-a-chip” – replicating organ functions in a microfluidic chip
Download this presentation (Powerpoint 22MB)

Ilka Maschmeyer – TissUse, Germany
The Multi-Organ-Chip – a novel approach to replace animal models in substance testing
Download this presentation (Powerpoint 75MB)

Lena Smirnova – CAAT, USA
3D brain models and microRNA to study developmental neurotoxicity
Download this presentation (Powerpoint 64MB)

Laura Bray– Leibniz Institute of Polymer Research, Germany
3D in-vitro cell culture models for studying acute myeloid leukaemia


B – Science & Training

Chaired by Brett Cochrane, Dr. Hadwen Trust

Christophe Mas – Oncotheis, Switzerland
A novel 3D human tissue culture model for in-vitro lung cancer research.
Download this presentation (Powerpoint 10MB)

Prof Michael L. Shuler – Cornell University, USA
“Body on a Chip”; In Vitro Human Models for Drug and Chemical Testing.>
Download this presentation (Powerpoint 10MB)

Dr. Gilly Stoddart – PETA International Science Consortium (PISC), UK
Minimising animal tests through education and training.
Download this presentation (Powerpoint 11.5MB)

Dmitry Leporsky – Ukraine
Replacement of animal experiments: Successes in the Ukraine and beyond.

Download this presentation (Powerpoint 18MB)


C – Public Awareness and Lobbying

Chaired by Nick Jukes, InterNICHE

Friedrich Mülln – SOKO Tierschutz e.V., Germany
Operation Alekto:revealing the truth about vivsection.
Download this presentation (Powerpoint 24MB)

Jeremy Beckham The Beagle Freedom Project, USA
Beagle Freedom Project’s Identity Campaign.
Download this presentation (Powerpoint 14MB)

Mojo Mathers MP New Zealand
Lobbying to ban animal testing of cosmetics in New Zealand.
Download this presentation (Powerpoint 45MB)



Session 3 – Update on alternatives to animal testing in China

Professor Shu Jun Cheng – Director of Toxicology Department, Guangdong Inspection & Quarantine Bureau (AQSIQ) and Founder of the Chinese Centre for Alternatives Research & Evaluation (CCARE)
Promoting animal-free testing in China through the Bottom-Up Way
Download this presentation (Powerpoint 4MB)



Session 4 – AOPs and their role in the replacement of animals in product safety testing

Chaired by Rob Harrison, Lush Prize

G. Frank Gerberick – Central Product Safety, Procter & Gamble and Black Box Prizewinner
Black Box Lush Prize 2015: Skin Sensitization Adverse Outcome Pathway
Download this presentation (Powerpoint 10MB)

Dr Carol Treasure – Founder & Managing Director, XCELLR8 Ltd and Lush Prizewinner 2013
AOPs and a 1R Approach to Safety Testing for Cosmetics.
Download this presentation (Powerpoint 33MB)

Troy Seidle – Director of Research and Toxicology, HSI Canada and Lush Prize Judge
Lessons from toxicology: Developing a 21st century paradigm for medical research.
View presentation on Prezi